{"id":16687,"date":"2022-07-15T12:02:22","date_gmt":"2022-07-15T10:02:22","guid":{"rendered":"https:\/\/naturdao.com\/quan-i-qui-va-descobrir-la-histamina\/"},"modified":"2023-10-05T10:56:10","modified_gmt":"2023-10-05T08:56:10","slug":"quan-i-qui-va-descobrir-la-histamina","status":"publish","type":"post","link":"https:\/\/naturdao.com\/ca\/quan-i-qui-va-descobrir-la-histamina\/","title":{"rendered":"Quan i qui va descobrir la histamina?"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"16687\" class=\"elementor elementor-16687 elementor-16566\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-52c091d6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"52c091d6\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-30ab1f8e\" data-id=\"30ab1f8e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-75cb40d5 elementor-widget elementor-widget-text-editor\" data-id=\"75cb40d5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tLa histamina \u00e9s una amina bioactiva que se sintetitza per descarboxilaci\u00f3 del seu amino\u00e0cid precursor, la histidina, en una reacci\u00f3 enzim\u00e0tica descrita per primera vegada per Windaus i Vogt el 1907.\r\n<figure class=\"wp-block-image aligncenter size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"558\" height=\"135\" data-src=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-1.png\" class=\"wp-image-16575 lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" alt=\"\" \/><noscript><img decoding=\"async\" width=\"558\" height=\"135\" class=\"wp-image-16575\" src=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-1.png\" alt=\"\" srcset=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-1.png 558w, https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-1-400x97.png 400w, https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-1-300x73.png 300w\" sizes=\"(max-width: 558px) 100vw, 558px\" \/><\/noscript><figcaption>S\u00edntesi de histamina per descarboxilaci\u00f3 del seu precursor amino\u00e0cid<\/figcaption><\/figure>\r\nEl nom histamina prov\u00e9 del grec <em>histos<\/em> que significa teixit, perqu\u00e8 \u00e9s present en molts teixits de l&#8217;organisme.\r\n\r\nEls efectes fisiol\u00f2gics i fisiopatol\u00f2gics de la histamina a l&#8217;organisme van ser descrits per primera vegada el 1910 per Dale i Laidlaw, dos investigadors pioners que van estudiar les seves funcions al Wellcome Physiological Research Laboratories (Dale HH, Laidlaw PP. 1910)\r\n\r\nLa histamina es troba a tot el nostre organisme, encara que en concentracions m\u00e9s elevades en pulmons, pell i el tracte gastrointestinal. Se sintetitza i emmagatzema principalment en bas\u00f2fils i mast\u00f2cits, i tamb\u00e9 en c\u00e8l\u00b7lules enterocromafins g\u00e0striques, ganglis limf\u00e0tics i t\u00edmus (Panula P, et al. 2015).\r\n\r\nEst\u00e0 involucrada en diversos mecanismes tant immunol\u00f2gics com fisiol\u00f2gics: estimulant la secreci\u00f3 d&#8217;\u00e0cid g\u00e0stric, en el proc\u00e9s de la inflamaci\u00f3, la contracci\u00f3 de les c\u00e8l\u00b7lules del m\u00fascul llis, la vasodilataci\u00f3 i la producci\u00f3 de citocines, entre d&#8217;altres. (Maintz. L. 2007; Vlieg-Boerstra BJ. Et al. 2005).\r\n<h2>La histamina \u00e9s un mediador del sistema neuro-immuno-endocr\u00ed<\/h2>\r\nA m\u00e9s, tamb\u00e9 funciona com a neurotransmissor, sent sintetitzada per neurones ubicades a la regi\u00f3 posterior de l&#8217;hipot\u00e0lem els axons del qual s&#8217;estenen per tot el cervell. (Gusano J, et al. 2019).\r\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" data-src=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-2.png\" class=\"wp-image-16583 lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" alt=\"\" width=\"665\" height=\"471\" \/><noscript><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-16583\" src=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-2.png\" alt=\"\" width=\"665\" height=\"471\" srcset=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-2.png 423w, https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-2-300x213.png 300w\" sizes=\"(max-width: 665px) 100vw, 665px\" \/><\/noscript><\/figure>\r\nLa variabilitat dels efectes fisiol\u00f2gics es produeix per la interacci\u00f3 amb quatre receptors diferents: H1, H2, H3 i H4, que activen vies de transducci\u00f3 de senyals en percebre la histamina. (Panula P, et al. 2015).\r\n\r\n<strong>Es coneixen dues vies metab\u00f2liques principals de la histamina que involucren dos enzims:<\/strong>\r\n<ul>\r\n \t<li>La DiAmino Oxidasa (DAO)<\/li>\r\n \t<li>Histamina-N-Metiltransferasa (HNMT)<\/li>\r\n<\/ul>\r\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" data-src=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-3.png\" class=\"wp-image-16595 lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" alt=\"\" width=\"589\" height=\"701\" \/><noscript><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-16595\" src=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-3.png\" alt=\"\" width=\"589\" height=\"701\" srcset=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-3.png 422w, https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-3-400x476.png 400w, https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-3-252x300.png 252w\" sizes=\"(max-width: 589px) 100vw, 589px\" \/><\/noscript><figcaption>Metabolisme de la histamina en humans<\/figcaption><\/figure>\r\n<h2>I quan es va iniciar la investigaci\u00f3 amb patologies o malalties?<\/h2><p class=\"nar-resposta\">Fa m\u00e9s de cent anys. Des que es va a\u00efllar, a principis del segle XX, la histamina es va relacionar amb les al\u00b7l\u00e8rgies, la inflamaci\u00f3 i els trastorns digestius, i es va convertir en objecte d&#8217;estudi cl\u00ednic. Els primers antihistam\u00ednics d&#8217;\u00fas cl\u00ednic van arribar fa uns setanta anys.<\/p>\r\n\r\n\r\nL&#8217;any 1926, Harmer i Harris van ser els primers cient\u00edfics a descriure la relaci\u00f3 entre el mal de cap i la histamina despr\u00e9s de subministrar en l&#8217;estudi una infusi\u00f3 d&#8217;aquesta (Harmer IM, 1926).\r\n\r\nEl 1927 es va purificar per primera vegada a partir de teixits humans.\r\n\r\nEl 1930, el cient\u00edfic Pickering va realitzar una s\u00e8rie d&#8217;estudis experimentals. Tot i que cap d&#8217;ells no va ser controlat amb placebo, la histamina va ser investigada de nou per la seva capacitat per induir mal de cap d&#8217;origen vascular. Es va demostrar que la histamina indu\u00efa el mal de cap de manera dependent de la dosi que es subministrava i de la susceptibilitat del subjecte, per\u00f2 que hi havia una gran variabilitat entre ells.\r\n\r\nL&#8217;investigador Pickering va proposar que l&#8217;origen de la cefalea relacionada amb la histamina d&#8217;origen vascular era per la vasodilataci\u00f3 de les art\u00e8ries intracranials i que a trav\u00e9s del nervi trig\u00e8min podria sorgir el mal de cap (Pickering GW, 1933).\r\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" data-src=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-4.png\" class=\"wp-image-16604 lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" alt=\"\" width=\"731\" height=\"421\" \/><noscript><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-16604\" src=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-4.png\" alt=\"\" width=\"731\" height=\"421\" srcset=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-4.png 591w, https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-4-400x230.png 400w, https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-4-300x173.png 300w\" sizes=\"(max-width: 731px) 100vw, 731px\" \/><\/noscript><figcaption>Cronologia hist\u00f2rica de la histamina i els receptors. Reimpr\u00e8s de (11) Copyright\u00a9 2011 amb autoritzaci\u00f3 d&#8217;Elsevier, J Allergy Clin Immunol<\/figcaption><\/figure>\r\nL&#8217;estudi de la relaci\u00f3 entre la histamina i la migranya s&#8217;ha continuat investigant durant molts anys i altres cient\u00edfics van analitzar com la histamina podia induir cefalees.\r\n\r\nM\u00e9s endavant, Northfield va injectar la histamina a l&#8217;art\u00e8ria car\u00f2tida externa i interna i va concloure que el mal de cap podria originar-se a l&#8217;art\u00e8ria car\u00f2tida interna (DWC de Northfield, 1938).\r\n\r\nVon Storch va estudiar sobre quina podrien ser les dosis m\u00ednimes d&#8217;histamina per induir mal de cap en una persona, per\u00f2, va observar que depenien del context, ja que aquelles persones que patien migranya de base i van ser seleccionades a l&#8217;estudi eren molt m\u00e9s susceptibles a patir mal de cap indu\u00eft pel subministrament d&#8217;histamina que els subjectes que no patien migranyes. (Arch Neurol Psychiatr. 1940; 44 :316\u2013322)\r\n\r\nPer tant, la literatura cient\u00edfica m\u00e9s antiga demostra la relaci\u00f3 entre les histamina i les cefalees.\r\n\r\nAvui dia, els investigadors continuen investigant els mediadors end\u00f2gens, inclosa la histamina, per la seva capacitat per generar mal de migranya i altres patologies i malalties. (De Logu F, et al. 2019).\r\n\r\nA m\u00e9s, la ci\u00e8ncia avan\u00e7a i cada cop van sorgint m\u00e9s estudis on relacionen la histamina com a mediador en diferents patologies i malalties.\r\n\r\nUna altra dada important que s&#8217;observa als estudis recents \u00e9s que depenent de la seva localitzaci\u00f3, la histamina present a l&#8217;organisme \u00e9s desaminada o metilada per l&#8217;acci\u00f3 dels enzims DAO i\/o HNMT (histamina-N-metiltransferasa) respectivament. (Maintz, L. 2015)\r\n\r\nCal distingir que l&#8217;enzim DAO \u00e9s responsable de la degradaci\u00f3 de la histamina extracel\u00b7lular. Aquest enzim s&#8217;expressa principalment a l&#8217;intest\u00ed prim, el c\u00f2lon ascendent, la placenta i els ronyons.\r\n\r\nA l&#8217;intest\u00ed, l&#8217;activitat de la DAO augmenta progressivament des del duod\u00e8 fins a l&#8217;ili i es localitza principalment a les vellositats intestinals. (Eisenhans, B. 1999)\r\n\r\nLa DAO tamb\u00e9 pot metabolitzar altres amines biog\u00e8niques com la putrescina i la cadaverina. (Elmore Bo, et al. 2002).\r\n\r\nL&#8217;enzim HNMT s&#8217;expressa en diversos teixits i \u00f2rgans del nostre cos, sobretot als ronyons i el fetge, tamb\u00e9 a la melsa, el c\u00f2lon, la pr\u00f2stata, els ovaris, les c\u00e8l\u00b7lules de la medul\u00b7la espinal, la tr\u00e0quea i el tracte respiratori . (Maintz, L. 2007).\r\n<h2>La principal via d&#8217;entrada al cos per a la histamina que procedeix dels aliments \u00e9s l&#8217;epiteli intestinal.<\/h2>\r\nPer tant, encara que la HNMT tamb\u00e9 \u00e9s present al tracte gastrointestinal, l&#8217;enzim DAO \u00e9s qui juga un paper principal en la protecci\u00f3 del cos contra la histamina ex\u00f2gena, aquella que procedeix dels aliments. (Bohem T. et al. 2019; Mar\u0161avelski A, et al 2018)\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>La histamina \u00e9s una amina bioactiva que se sintetitza per descarboxilaci\u00f3 del seu amino\u00e0cid precursor, la histidina, en una reacci\u00f3 enzim\u00e0tica descrita per primera vegada per Windaus i Vogt el 1907. S\u00edntesi de histamina per descarboxilaci\u00f3 del seu precursor amino\u00e0cid El nom histamina prov\u00e9 del grec histos que significa teixit, perqu\u00e8 \u00e9s present en molts [&hellip;]<\/p>\n","protected":false},"author":872,"featured_media":195997,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[26],"tags":[],"class_list":["post-16687","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.1.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"La histamina \u00e9s un mediador del sistema neuro-immuno-endocr\u00ed, els efectes del qual en el nostre organisme van ser descrits per primera vegada el 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