{"id":201065,"date":"2025-05-08T10:03:35","date_gmt":"2025-05-08T08:03:35","guid":{"rendered":"https:\/\/naturdao.com\/la-histamina-en-les-malalties-autoimmunes-una-perspectiva-integradora-i-clinica\/"},"modified":"2025-05-09T10:22:28","modified_gmt":"2025-05-09T08:22:28","slug":"la-histamina-en-les-malalties-autoimmunes-una-perspectiva-integradora-i-clinica","status":"publish","type":"post","link":"https:\/\/naturdao.com\/ca\/la-histamina-en-les-malalties-autoimmunes-una-perspectiva-integradora-i-clinica\/","title":{"rendered":"La histamina en les malalties autoimmunes: una perspectiva integradora i cl\u00ednica"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"201065\" class=\"elementor elementor-201065 elementor-201043\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-59c65e2 e-flex e-con-boxed e-con e-parent\" data-id=\"59c65e2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8b73a87 elementor-widget elementor-widget-text-editor\" data-id=\"8b73a87\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Sabies que la histamina no nom\u00e9s est\u00e0 relacionada amb les al\u00b7l\u00e8rgies, sin\u00f3 tamb\u00e9 amb malalties autoimmunes com l&#8217;hipotiro\u00efdisme de Hashimoto, el lupus, l&#8217;esclerosi m\u00faltiple o l&#8217;artritis reumatoide?<\/p>\n<p>En aquest article t\u2019explico, pas a pas, com la histamina i unes c\u00e8l\u00b7lules anomenades mast\u00f2cits poden influir en el desenvolupament i evoluci\u00f3 d\u2019aquestes malalties. I sobretot, com entendre-ho per ajudar-te a cuidar la teva salut d\u2019una manera m\u00e9s personalitzada.<\/p>\n<p><strong>Histamina i Hipotiro\u00efdisme Autoimmune: Quina relaci\u00f3 tenen?<\/strong><\/p>\n<p>L\u2019hipotiro\u00efdisme autoimmune, tamb\u00e9 conegut com a tiroiditis de Hashimoto, ocorre quan el sistema immunitari ataca per error la gl\u00e0ndula tiroide, afectant-ne el funcionament.<\/p>\n<p>Diversos estudis han demostrat que moltes persones amb Hashimoto tamb\u00e9 presenten problemes i s\u00edmptomes relacionats amb la histamina: urtic\u00e0ria, migranyes, sensibilitat digestiva o fatiga.<\/p>\n<p>Un fet destacable: les persones amb urtic\u00e0ria cr\u00f2nica espont\u00e0nia (una afecci\u00f3 molt vinculada als mast\u00f2cits) tenen entre cinc i set vegades m\u00e9s risc de presentar anticossos contra la tiroide (anti-TPO).<\/p>\n<p>A m\u00e9s, un estudi experimental va mostrar que l\u2019hipotiro\u00efdisme augmenta tant la quantitat de mast\u00f2cits com els nivells de histamina als teixits. En altres paraules, la manca d\u2019hormona tiro\u00efdal pot fer que el cos sigui m\u00e9s sensible a la histamina, incrementant els s\u00edmptomes inflamatoris i empitjorant el benestar general.<\/p>\n<p>Tamb\u00e9 s\u2019ha proposat que la intoler\u00e0ncia a la histamina pot ser m\u00e9s freq\u00fcent en persones amb Hashimoto, a causa d\u2019alteracions concomitants en la microbiota intestinal o en l\u2019activitat de l\u2019enzim DAO, que metabolitza la histamina a l\u2019intest\u00ed. En conjunt, l\u2019estat inflamatori autoimmune podria agreujar l\u2019alliberament de histamina i, alhora, l\u2019exc\u00e9s de histamina pot incrementar la inflamaci\u00f3 tiro\u00efdal, creant un cercle vici\u00f3s.<\/p>\n<p>Controlar els nivells de histamina sovint forma part d\u2019enfocaments integratius per millorar els s\u00edmptomes d\u2019aquests pacients, encara que el fonament principal continua sent el control de l\u2019autoimmunitat tiro\u00efdal.<\/p>\n<p><strong>Histamina i Lupus: inflamaci\u00f3 amplificada<\/strong><\/p>\n<p>El lupus eritemat\u00f3s sist\u00e8mic (LES) \u00e9s una malaltia autoimmune complexa que afecta m\u00faltiples \u00f2rgans: pell, ronyons, articulacions, cor\u2026<\/p>\n<p>S\u2019ha observat que els teixits danyats pel lupus contenen una major quantitat de mast\u00f2cits activats que els teixits sans. Aquests mast\u00f2cits no nom\u00e9s alliberen histamina, sin\u00f3 tamb\u00e9 enzims que destrueixen teixits, com les metal\u00b7loprote\u00efnases (MMPs).<\/p>\n<p>A m\u00e9s, hi ha evid\u00e8ncia que la via de la histamina est\u00e0 implicada en la susceptibilitat al lupus. Un estudi gen\u00e8tic va trobar que certes variacions en el nombre de c\u00f2pies del gen del receptor H4 de la histamina s\u2019associaven amb un major risc de lupus eritemat\u00f3s sist\u00e8mic. El receptor H4 s\u2019expressa en c\u00e8l\u00b7lules immunit\u00e0ries (incloent-hi limf\u00f2cits T i c\u00e8l\u00b7lules dendr\u00edtiques) i participa en la quimiotaxi i modulaci\u00f3 de respostes Th1\/Th17. Alteracions en aquesta via podrien predisposar a respostes autoimmunes m\u00e9s intenses.<\/p>\n<p>A la pr\u00e0ctica cl\u00ednica, alguns pacients amb lupus presenten manifestacions al\u00b7l\u00e8rgiques (com urtic\u00e0ria o angioedema) durant els brots de la malaltia, cosa que suggereix que l\u2019alliberament de histamina i l\u2019activaci\u00f3 autoimmune poden oc\u00f3rrer en paral\u00b7lel. Tot i que el tractament principal del lupus requereix immunosupressors dirigits (com corticoides o f\u00e0rmacs biol\u00f2gics), el control dels s\u00edmptomes al\u00b7l\u00e8rgics amb antihistam\u00ednics pot ser \u00fatil com a ter\u00e0pia complement\u00e0ria.<\/p>\n<p>Per tant, tot aix\u00f2 suggereix que, en persones amb lupus, la histamina podria actuar com un <em>amplificador<\/em> de la resposta immune, empitjorant els brots i contribuint al dany als \u00f2rgans.<\/p>\n<p><strong>Esclerosi m\u00faltiple<\/strong><\/p>\n<p>L\u2019esclerosi m\u00faltiple (EM) \u00e9s una malaltia autoimmune del sistema nervi\u00f3s central, en qu\u00e8 el sistema immune ataca la mielina (una subst\u00e0ncia que recobreix els nervis) al cervell i la medul\u00b7la espinal.<\/p>\n<p>Els mast\u00f2cits s\u00f3n presents al sistema nervi\u00f3s i, quan s\u2019activen, augmenten la permeabilitat de la barrera hematoencef\u00e0lica, alliberant histamina, TNF-\u03b1, IL-1\u03b2 i proteases, permetent l\u2019entrada de c\u00e8l\u00b7lules inflamat\u00f2ries al SNC. Aquest mecanisme facilita la formaci\u00f3 de lesions desmielinitzants caracter\u00edstiques de l\u2019EM.<\/p>\n<p>De fet, s\u2019ha documentat que durant els brots d\u2019esclerosi m\u00faltiple hi ha m\u00e9s desgranulaci\u00f3 mastocit\u00e0ria al cervell, associada a l\u2019arribada de neutr\u00f2fils i limf\u00f2cits al teixit nervi\u00f3s.<\/p>\n<p>La histamina tamb\u00e9 pot influir en l\u2019equilibri de les respostes immunit\u00e0ries en aquesta malaltia. Encara que pot inclinar les respostes cap a un perfil Th2 en alguns contextos, en l\u2019EM (que \u00e9s predominantment Th1\/Th17), sembla tenir un paper m\u00e9s proinflamatori en reclutar c\u00e8l\u00b7lules al sistema nervi\u00f3s i activar limf\u00f2cits encefalitog\u00e8nics.<\/p>\n<p>Un fet interessant \u00e9s que els nivells de histamina en el l\u00edquid cefaloraquidi de pacients amb EM s\u00f3n m\u00e9s elevats que en persones sanes, donant suport a la hip\u00f2tesi d\u2019una activaci\u00f3 mastocit\u00e0ria\/neuroimmune.<\/p>\n<p>A m\u00e9s, alguns estudis en animals han trobat que l\u2019\u00fas d\u2019antihistam\u00ednics o estabilitzadors de mast\u00f2cits pot reduir la gravetat de la malaltia.<\/p>\n<p>Tot aix\u00f2 obre la porta a enfocaments complementaris en l\u2019EM, on, juntament amb els immunomoduladors espec\u00edfics, es podria considerar l\u2019\u00fas de bloquejadors de histamina o estabilitzadors de mast\u00f2cits per reduir la inflamaci\u00f3 neurog\u00e8nica.<\/p>\n<p>Tot i que encara no existeix una ter\u00e0pia est\u00e0ndard en EM dirigida a la histamina, les evid\u00e8ncies suggereixen que els nivells elevats de histamina poden agreujar la neuroinflamaci\u00f3, i que el seu control podria tenir un efecte modulador benefici\u00f3s.<\/p>\n<p><strong>Artritis reumatoide: dolor, histamina i dany articular<\/strong><\/p>\n<p>L\u2019artritis reumatoide \u00e9s una malaltia autoimmune cr\u00f2nica que afecta principalment les articulacions sinovials, causant inflamaci\u00f3 del revestiment, dolor i destrucci\u00f3 del cart\u00edlag i l\u2019os subjacents.<\/p>\n<p>En les articulacions inflamades de persones amb artritis reumatoide, s\u2019han trobat grans quantitats de mast\u00f2cits actius al teixit sinovial. En conseq\u00fc\u00e8ncia, mediadors com la histamina, la triptasa i la quimasa es troben elevats tant en el l\u00edquid sinovial com a la sang perif\u00e8rica.<\/p>\n<p>Aquesta alliberaci\u00f3 persistent de histamina contribueix a la vasodilataci\u00f3 i l\u2019augment de la permeabilitat vascular, provocant edema (inflor) i infiltraci\u00f3 de c\u00e8l\u00b7lules immunit\u00e0ries.<\/p>\n<p>La histamina tamb\u00e9 actua sobre receptors H1 en les terminacions nervioses, causant dolor i hipersensibilitat a l\u2019articulaci\u00f3 inflamada. A m\u00e9s, pot activar els osteoclasts, c\u00e8l\u00b7lules que degraden l\u2019os.<\/p>\n<p>En models animals, bloquejar el receptor H4 ha redu\u00eft significativament els s\u00edmptomes d\u2019artritis, cosa que suggereix que aquesta via podria ser una diana terap\u00e8utica futura.<\/p>\n<p><strong>Mast\u00f2cits i inflamaci\u00f3 cr\u00f2nica de baix grau<\/strong><\/p>\n<p>Els mast\u00f2cits s\u00f3n c\u00e8l\u00b7lules centinella del sistema immunitari innat que, quan s\u2019activen, alliberen una \u00e0mplia gamma de mediadors inflamatoris com la histamina, l\u2019heparina, la triptasa, la quimasa, citocines proinflamat\u00f2ries, prostaglandines i leucotriens.<\/p>\n<p>Un dels aspectes m\u00e9s rellevants per entendre la connexi\u00f3 entre histamina i autoimmunitat \u00e9s la inflamaci\u00f3 de baix grau. No es tracta d\u2019una inflamaci\u00f3 aguda, sin\u00f3 d\u2019un estat persistent, silenci\u00f3s, que mant\u00e9 el cos ences de forma cr\u00f2nica.<\/p>\n<p>Els mast\u00f2cits activats de manera continuada poden alliberar petites quantitats de histamina, suficients per mantenir aquesta inflamaci\u00f3 sense que ens n\u2019adonem al principi. Aquesta activaci\u00f3 persistent actua com una espurna que no s\u2019apaga, mantenint l\u2019autoimmunitat.<\/p>\n<p>Un aspecte interessant \u00e9s la possible connexi\u00f3 entre factors ambientals o diet\u00e8tics i l\u2019activaci\u00f3 mastocit\u00e0ria en l\u2019autoimmunitat. Per exemple, certes bacteris intestinals o aliments rics en histamina podrien elevar el to histam\u00ednic sist\u00e8mic, afegint combustible a aquesta inflamaci\u00f3 de baix grau.<\/p>\n<p>A m\u00e9s, el s\u00edndrome d\u2019activaci\u00f3 mastocit\u00e0ria (MCAS) s\u2019ha descrit amb m\u00e9s freq\u00fc\u00e8ncia en pacients amb malalties autoimmunes, incloent-hi l\u2019autoimmunitat tiro\u00efdal i les malalties del teixit connectiu.<\/p>\n<p>Tot aix\u00f2 suggereix que en alguns pacients, l\u2019autoimmunitat i la hiperreactivitat mastocit\u00e0ria poden coexistir, i ambdues han de ser abordades.<\/p>\n<p><strong>I qu\u00e8 podem fer?<\/strong><\/p>\n<p>Encara que calen m\u00e9s estudis, alguns enfocaments des de la psiconeuroimmunologia poden ajudar a regular aquesta interacci\u00f3:<\/p>\n<ul>\n<li>Seguir una dieta antiinflamat\u00f2ria i, en alguns casos, baixa en histamina.<\/li>\n<li>Tractar la disbiosi intestinal, refor\u00e7ant la barrera mucosa.<\/li>\n<li>Consumir aliments rics en compostos que estabilitzen els mast\u00f2cits: quercetina, lute\u00efna, omega-3, c\u00farcuma\u2026<\/li>\n<li>Evitar l\u2019alcohol, aliments ultraprocessats o aquells que afavoreixen l\u2019alliberament de histamina.<\/li>\n<li>Utilitzar suplements de Naturdao en el context que ho requereixi, aix\u00ed com estabilitzadors de mast\u00f2cits.<\/li>\n<li>Regular l\u2019estr\u00e8s i l\u2019activaci\u00f3 cr\u00f2nica del sistema nervi\u00f3s simp\u00e0tic.<\/li>\n<\/ul>\n<p>En resum, comprendre com interactuen els mast\u00f2cits, la histamina i el sistema immune ens obre la porta a enfocaments m\u00e9s personalitzats i integradors per abordar malalties autoimmunes com Hashimoto, lupus, esclerosi m\u00faltiple o artritis reumatoide.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-474ab05 e-flex e-con-boxed e-con e-parent\" data-id=\"474ab05\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3470c45 elementor-widget elementor-widget-text-editor\" data-id=\"3470c45\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>REFERENCIES<\/strong><\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ecaf377 elementor-widget elementor-widget-text-editor\" data-id=\"ecaf377\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol>\n<li>Tienforti D, Di Giulio F, Spagnolo L, <em>et al.<\/em> Chronic urticaria and thyroid autoimmunity: a meta-analysis of case\u2013control studies. <em>J Endocrinol Invest.<\/em> 2022;45(7):1317-1326.<\/li>\n<li>Chieffi Baccari G, Falvo S, Lanni A, <em>et al.<\/em> Mast cell population and histamine content in hypothyroid rat tissues. <em>Animals (Basel).<\/em> 2022;12(14):1840.<\/li>\n<li>Noto CN, Hoft SG, DiPaolo RJ. Mast cells as important regulators in autoimmunity and cancer development. <em>Front Cell Dev Biol.<\/em> 2021;9:752350.<\/li>\n<li>Gutowski \u0141, Kanikowski S, Formanowicz D. Mast cell involvement in the pathogenesis of selected musculoskeletal diseases. <em>Life (Basel).<\/em> 2023;13(8):1690.<\/li>\n<li>Pinke KH, Lara VS, Sartori A. Should mast cells be considered therapeutic targets in multiple sclerosis?<em>Neural Regen Res.<\/em> 2020;15(12):2182-2189.<\/li>\n<li>Volont\u00e9 C, Apolloni S, Amadio S. The histamine and multiple sclerosis alliance: pleiotropic actions and functional validation.<em>Curr Top Behav Neurosci.<\/em> 2022;59:217-239.<\/li>\n<li>Tedla N, Bandeira-Melo C, Tassinari P, <em>et al.<\/em> Ultraviolet radiation\u2013induced cytokines promote mast cell accumulation and matrix metalloproteinase production: potential role in cutaneous lupus erythematosus. <em>Scand J Rheumatol.<\/em> 2011;40(3):197-204.<\/li>\n<\/ol>\n<p>\u00a0<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Sabies que la histamina no nom\u00e9s est\u00e0 relacionada amb les al\u00b7l\u00e8rgies, sin\u00f3 tamb\u00e9 amb malalties autoimmunes com l&#8217;hipotiro\u00efdisme de Hashimoto, el lupus, l&#8217;esclerosi m\u00faltiple o l&#8217;artritis reumatoide? En aquest article t\u2019explico, pas a pas, com la histamina i unes c\u00e8l\u00b7lules anomenades mast\u00f2cits poden influir en el desenvolupament i evoluci\u00f3 d\u2019aquestes malalties. I sobretot, com entendre-ho [&hellip;]<\/p>\n","protected":false},"author":1097,"featured_media":201054,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[26],"tags":[],"class_list":["post-201065","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.0.1 - aioseo.com -->\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"yasmina\"\/>\n\t<meta name=\"google-site-verification\" content=\"googlec0b8607c1a0a6fdc.html\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/naturdao.com\/ca\/la-histamina-en-les-malalties-autoimmunes-una-perspectiva-integradora-i-clinica\/\" 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