{"id":197110,"date":"2024-01-15T12:05:59","date_gmt":"2024-01-15T11:05:59","guid":{"rendered":"https:\/\/naturdao.com\/histamine-and-histamine-intolerance\/"},"modified":"2024-03-04T14:07:27","modified_gmt":"2024-03-04T13:07:27","slug":"histamine-and-histamine-intolerance","status":"publish","type":"post","link":"https:\/\/naturdao.com\/en\/histamine-and-histamine-intolerance\/","title":{"rendered":"Histamine and histamine intolerance"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"197110\" class=\"elementor elementor-197110 elementor-196411\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6fe7a379 e-flex e-con-boxed e-con e-parent\" data-id=\"6fe7a379\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-507b2fe8 e-flex e-con-boxed e-con e-child\" data-id=\"507b2fe8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-776e6bdd e-con-full e-flex e-con e-child\" data-id=\"776e6bdd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-64ede394 elementor-widget elementor-widget-image\" data-id=\"64ede394\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"622\" height=\"834\" src=\"https:\/\/naturdao.com\/wp-content\/uploads\/2024\/01\/histamine_and_histamine_intolerance.jpg\" class=\"attachment-large size-large wp-image-196422\" alt=\"\" srcset=\"https:\/\/naturdao.com\/wp-content\/uploads\/2024\/01\/histamine_and_histamine_intolerance.jpg 622w, https:\/\/naturdao.com\/wp-content\/uploads\/2024\/01\/histamine_and_histamine_intolerance-224x300.jpg 224w\" sizes=\"(max-width: 622px) 100vw, 622px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-54a06a6e e-con-full e-flex e-con e-child\" data-id=\"54a06a6e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-563feb70 elementor-widget elementor-widget-theme-post-title elementor-page-title elementor-widget-heading\" data-id=\"563feb70\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-title.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Histamine and histamine intolerance<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1de6cbe6 elementor-align-start elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"1de6cbe6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-user\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Laura Maintz, Natalija Novak<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-newspaper\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">The American Journal of Clinical Nutrition Volume 85, Issue 5, May 2007, Pages 1185-1196<br><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/doi.org\/10.1093\/ajcn\/85.5.1185\" target=\"_blank\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-archive\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">https:\/\/doi.org\/10.1093\/ajcn\/85.5.1185 <br><\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-comment\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">ENGLISH<br><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-36446861 e-flex e-con-boxed e-con e-parent\" data-id=\"36446861\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2d5e9f70 elementor-widget elementor-widget-text-editor\" data-id=\"2d5e9f70\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><strong>ABSTRACT<\/strong><\/span><\/p>\n<p>Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation.<\/p>\n<p>Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity.<\/p>\n<p>Diamine oxidase (DAO) is the main enzyme for the metabolism of ingested histamine. It has been proposed that DAO, when functioning as a secretory protein, may be responsible for scavenging extracellular histamine after mediator release.<\/p>\n<p>Conversely, histamine\u00a0<em>N<\/em>-methyltransferase, the other important enzyme inactivating histamine, is a cytosolic protein that can convert histamine only in the intracellular space of cells.<\/p>\n<p>An impaired histamine degradation based on reduced DAO activity and the resulting histamine excess may cause numerous symptoms mimicking an allergic reaction.<\/p>\n<p>The ingestion of histamine-rich food or of alcohol or drugs that release histamine or block DAO may provoke diarrhea, headache, rhinoconjunctival symptoms, asthma, hypotension, arrhythmia, urticaria, pruritus, flushing, and other conditions in patients with histamine intolerance.<\/p>\n<p>Symptoms can be reduced by a histamine-free diet or be eliminated by antihistamines. However, because of the multifaceted nature of the symptoms, the existence of histamine intolerance has been underestimated, and further studies based on double-blind, placebo-controlled provocations are needed.<\/p>\n<p>In patients in whom the abovementioned symptoms are triggered by the corresponding substances and who have a negative diagnosis of allergy or internal disorders, histamine intolerance should be considered as an underlying pathomechanism.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-72010ac3 e-flex e-con-boxed e-con e-parent\" data-id=\"72010ac3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-60047df9 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"60047df9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-xl\" href=\"https:\/\/ajcn.nutrition.org\/article\/S0002-9165(23)28053-3\/fulltext#%20\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-file-pdf\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read full article <\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Laura Maintz, Natalija Novak The American Journal of Clinical Nutrition Volume 85, Issue 5, May 2007, Pages 1185-1196 https:\/\/doi.org\/10.1093\/ajcn\/85.5.1185 ENGLISH ABSTRACT Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can [&hellip;]<\/p>\n","protected":false},"author":1097,"featured_media":196552,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[169],"tags":[],"class_list":["post-197110","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-studies"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.0.1 - aioseo.com -->\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"yasmina\"\/>\n\t<meta name=\"google-site-verification\" content=\"googlec0b8607c1a0a6fdc.html\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/naturdao.com\/en\/histamine-and-histamine-intolerance\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.0.1\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/naturdao.com\\\/en\\\/histamine-and-histamine-intolerance\\\/#article\",\"name\":\"Histamine and histamine intolerance | NATURDAO\",\"headline\":\"Histamine and histamine intolerance\",\"author\":{\"@id\":\"https:\\\/\\\/naturdao.com\\\/en\\\/author\\\/yasmina\\\/#author\"},\"publisher\":{\"@id\":\"https:\\\/\\\/naturdao.com\\\/en\\\/#organization\"},\"image\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/naturdao.com\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/epitelio_DAO_HNMTc-scaled.jpg\",\"width\":2560,\"height\":555},\"datePublished\":\"2024-01-15T12:05:59+01:00\",\"dateModified\":\"2024-03-04T14:07:27+01:00\",\"inLanguage\":\"en-US\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/naturdao.com\\\/en\\\/histamine-and-histamine-intolerance\\\/#webpage\"},\"isPartOf\":{\"@id\":\"https:\\\/\\\/naturdao.com\\\/en\\\/histamine-and-histamine-intolerance\\\/#webpage\"},\"articleSection\":\"Studies, Optional\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/naturdao.com\\\/en\\\/histamine-and-histamine-intolerance\\\/#breadcrumblist\",\"itemListElement\":[{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/naturdao.com\\\/en\\\/#listItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/naturdao.com\\\/en\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/naturdao.com\\\/en\\\/category\\\/studies\\\/#listItem\",\"name\":\"Studies\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/naturdao.com\\\/en\\\/category\\\/studies\\\/#listItem\",\"position\":2,\"name\":\"Studies\",\"item\":\"https:\\\/\\\/naturdao.com\\\/en\\\/category\\\/studies\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/naturdao.com\\\/en\\\/histamine-and-histamine-intolerance\\\/#listItem\",\"name\":\"Histamine and histamine intolerance\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/naturdao.com\\\/en\\\/#listItem\",\"name\":\"Home\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/naturdao.com\\\/en\\\/histamine-and-histamine-intolerance\\\/#listItem\",\"position\":3,\"name\":\"Histamine and histamine intolerance\",\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/naturdao.com\\\/en\\\/category\\\/studies\\\/#listItem\",\"name\":\"Studies\"}}]},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/naturdao.com\\\/en\\\/#organization\",\"name\":\"GLOBAL MOPI SL\",\"description\":\"Complemento alimenticio de Diamino Oxidasa - 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