{"id":16765,"date":"2022-07-15T12:02:22","date_gmt":"2022-07-15T10:02:22","guid":{"rendered":"https:\/\/naturdao.com\/quand-fut-decouverte-lhistamine-et-par-qui\/"},"modified":"2022-07-20T15:28:51","modified_gmt":"2022-07-20T13:28:51","slug":"quand-fut-decouverte-lhistamine-et-par-qui","status":"publish","type":"post","link":"https:\/\/naturdao.com\/fr\/quand-fut-decouverte-lhistamine-et-par-qui\/","title":{"rendered":"Quand fut d\u00e9couverte l\u2019histamine et par qui?"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"16765\" class=\"elementor elementor-16765 elementor-16566\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-52c091d6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"52c091d6\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-30ab1f8e\" data-id=\"30ab1f8e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-75cb40d5 elementor-widget elementor-widget-text-editor\" data-id=\"75cb40d5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tL&#8217;histamine, amine bioactive, est synth\u00e9tis\u00e9e par d\u00e9carboxylation de son acide amin\u00e9 pr\u00e9curseur, l&#8217;histidine, dans une r\u00e9action enzymatique d\u00e9crite pour la premi\u00e8re fois par Windaus et Vogt en 1907.\r\n<figure class=\"wp-block-image aligncenter size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"558\" height=\"135\" class=\"wp-image-16579\" src=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-1.png\" alt=\"\" srcset=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-1.png 558w, https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-1-400x97.png 400w, https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-1-300x73.png 300w\" sizes=\"(max-width: 558px) 100vw, 558px\" \/><figcaption>Synth\u00e8se d&#8217;histamine par d\u00e9carboxylation de son acide amin\u00e9 pr\u00e9curseur\r\n\r\n<\/figcaption><\/figure>\r\nLe nom histamine vient du grec histos signifiant tissu, car il est pr\u00e9sent dans de nombreux tissus de l&#8217;organisme.\r\n\r\nLes effets physiologiques et physiopathologiques de l&#8217;histamine dans le corps ont \u00e9t\u00e9 d\u00e9crits pour la premi\u00e8re fois en 1910 par Dale et Laidlaw, deux chercheurs pionniers qui ont \u00e9tudi\u00e9 ses fonctions aux Wellcome Physiological Research Laboratories (Dale HH, Laidlaw PP. 1910).\r\n\r\nL&#8217;histamine est pr\u00e9sente dans tout notre corps, bien qu&#8217;\u00e0 des concentrations plus \u00e9lev\u00e9es dans les poumons, la peau et le tractus gastro-intestinal. Il est synth\u00e9tis\u00e9 et stock\u00e9 principalement dans les basophiles et les mastocytes, ainsi que dans les cellules ent\u00e9rochromaffines gastriques, les ganglions lymphatiques et le thymus (Panula P, et al. 2015).\r\n\r\nIl est impliqu\u00e9 dans divers m\u00e9canismes immunologiques et physiologiques : stimulation de la s\u00e9cr\u00e9tion d&#8217;acide gastrique, dans le processus d&#8217;inflammation, la contraction des cellules musculaires lisses, la vasodilatation et la production de cytokines, entre autres. (Maintz. L. 2007; Vlieg-Boerstra BJ. Et al. 2005).\r\n<h2>L&#8217;histamine est un m\u00e9diateur du syst\u00e8me neurologique, immunitaire et endocrinien<\/h2>\r\nEn outre, il fonctionne \u00e9galement comme un neurotransmetteur, \u00e9tant synth\u00e9tis\u00e9 par des neurones situ\u00e9s dans la r\u00e9gion post\u00e9rieure de l&#8217;hypothalamus dont les axones s&#8217;\u00e9tendent dans tout le cerveau. (Worm J, et al. 2019).\r\n\r\n&nbsp;\r\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" class=\"wp-image-16587\" src=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-2.png\" alt=\"\" width=\"665\" height=\"471\" srcset=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-2.png 423w, https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-2-300x213.png 300w\" sizes=\"(max-width: 665px) 100vw, 665px\" \/><\/figure>\r\nLa variabilit\u00e9 de ses effets physiologiques est produite par l&#8217;interaction avec quatre r\u00e9cepteurs diff\u00e9rents : H1, H2, H3 et H4, qui activent les voies de transduction du signal lors de la perception de l&#8217;histamine. (Panula P, et al. 2015).\r\n\r\n<strong>On conna\u00eet deux principales voies m\u00e9taboliques de l&#8217;histamine qui impliquent deux enzymes:<\/strong>\r\n<ul>\r\n \t<li>Diamine oxydase (DAO)<\/li>\r\n \t<li>Histamine-N-m\u00e9thyltransf\u00e9rase (HNMT)<\/li>\r\n<\/ul>\r\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" class=\"wp-image-16599\" src=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-3.png\" alt=\"\" width=\"589\" height=\"701\" srcset=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-3.png 422w, https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-3-400x476.png 400w, https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-3-252x300.png 252w\" sizes=\"(max-width: 589px) 100vw, 589px\" \/><figcaption>M\u00e9tabolisme de l&#8217;histamine chez l&#8217;homme\r\n\r\n<\/figcaption><\/figure>\r\n<h2>A quelle date ont d\u00e9but\u00e9 vos recherches relatives \u00e0 ces pathologies ou maladies?<\/h2>\r\nEh bien, il y a plus de cent ans. Les premiers antihistaminiques \u00e0 \u00eatre mis en usage clinique remontent \u00e0 environ 70 ans. En 1926, Harmer et Harris ont \u00e9t\u00e9 les premiers scientifiques \u00e0 d\u00e9crire la relation entre les maux de t\u00eate et l&#8217;histamine apr\u00e8s avoir un apport d\u2019histamine \u00e0 l\u2019\u00e9tude. (Harmer IM, 1926)\r\n\r\nEn 1927, il a \u00e9t\u00e9 purifi\u00e9 pour la premi\u00e8re fois \u00e0 partir de tissus humains.\r\n\r\nEn 1930, le scientifique Pickering a men\u00e9 une s\u00e9rie d&#8217;\u00e9tudes exp\u00e9rimentales. Bien qu&#8217;aucun d&#8217;entre eux n&#8217;ait \u00e9t\u00e9 contr\u00f4l\u00e9 par placebo, l&#8217;histamine a \u00e9t\u00e9 \u00e9tudi\u00e9e plus avant pour sa capacit\u00e9 \u00e0 induire des maux de t\u00eate vasculaires. Il a \u00e9t\u00e9 d\u00e9montr\u00e9 que l&#8217;histamine induisait des maux de t\u00eate d&#8217;une mani\u00e8re d\u00e9pendante de la dose et de la sensibilit\u00e9, mais il y avait une grande variabilit\u00e9 entre eux.\r\n\r\nLe chercheur Pickering a propos\u00e9 que l&#8217;origine des c\u00e9phal\u00e9es d&#8217;origine vasculaire li\u00e9es \u00e0 l&#8217;histamine \u00e9tait due \u00e0 la vasodilatation des art\u00e8res intracr\u00e2niennes et que la c\u00e9phal\u00e9e pouvait provenir du nerf trijumeau (Pickering GW, 1033).\r\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-16608\" src=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-4.png\" alt=\"\" width=\"731\" height=\"421\" srcset=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-4.png 591w, https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-4-400x230.png 400w, https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/image-4-300x173.png 300w\" sizes=\"(max-width: 731px) 100vw, 731px\" \/><figcaption>Chronologie historique de l&#8217;histamine et de ses r\u00e9cepteurs. R\u00e9imprim\u00e9 de (11) Copyright\u00a9 2011 avec la permission d&#8217;Elsevier, J Allergy Clin Immunol\r\n\r\n<\/figcaption><\/figure>\r\nL&#8217;\u00e9tude de la relation entre l&#8217;histamine et la migraine est \u00e9tudi\u00e9e depuis de nombreuses ann\u00e9es et d&#8217;autres scientifiques ont analys\u00e9 comment l&#8217;histamine pouvait induire des maux de t\u00eate.\r\n\r\n&nbsp;\r\n\r\nPlus tard, Northfield a inject\u00e9 de l&#8217;histamine dans les art\u00e8res carotides externes et internes et a conclu que le mal de t\u00eate pouvait provenir de l&#8217;art\u00e8re carotide interne (Northfield&#8217;s DWC, 1938).\r\n\r\n&nbsp;\r\n\r\nVon Storch a \u00e9tudi\u00e9 quelles pouvaient \u00eatre les doses minimales d&#8217;histamine pour induire un mal de t\u00eate chez une personne, cependant, il a observ\u00e9 qu&#8217;elles d\u00e9pendaient du contexte, puisque les personnes souffrant de migraine et s\u00e9lectionn\u00e9es dans l&#8217;\u00e9tude \u00e9taient beaucoup plus susceptibles de souffrir de maux de t\u00eate. Induite par l&#8217;administration d&#8217;histamine que les sujets sans migraines. (Arch Neurol Psychiatr. 1940; 44: 316\u2013322)\r\n\r\nPar cons\u00e9quent, la litt\u00e9rature scientifique la plus ancienne d\u00e9montre la relation entre les histamines et les maux de t\u00eate.\r\n\r\n\u00c0 ce jour, les chercheurs continuent d&#8217;\u00e9tudier les m\u00e9diateurs endog\u00e8nes, y compris l&#8217;histamine, pour leur capacit\u00e9 \u00e0 g\u00e9n\u00e9rer des douleurs migraineuses et d&#8217;autres pathologies et maladies. (De Logu F, et al. 2019).\r\n\r\nDe plus, la science progresse et de plus en plus d&#8217;\u00e9tudes \u00e9mergent o\u00f9 l&#8217;histamine est li\u00e9e en tant que m\u00e9diateur dans diff\u00e9rentes pathologies et maladies.\r\n\r\nUne autre information importante observ\u00e9e dans des \u00e9tudes r\u00e9centes est que, selon sa localisation, l&#8217;histamine pr\u00e9sente dans l&#8217;organisme est d\u00e9samin\u00e9e ou m\u00e9thyl\u00e9e sous l&#8217;action des enzymes DAO et\/ou HNMT (histamine-N-m\u00e9thyltransf\u00e9rase), respectivement. (Maintz, L. 2015)\r\n\r\nIl est \u00e0 noter que l&#8217;enzyme DAO est responsable de la d\u00e9gradation de l&#8217;histamine extracellulaire. Cette enzyme est principalement exprim\u00e9e dans l&#8217;intestin gr\u00eale, le c\u00f4lon ascendant, le placenta et les reins.\r\n\r\nDans l&#8217;intestin, l&#8217;activit\u00e9 DAO augmente progressivement du duod\u00e9num vers l&#8217;il\u00e9on et se situe principalement dans les villosit\u00e9s intestinales. (Eisenhans, B. 1999)\r\n\r\nDAO peut \u00e9galement m\u00e9taboliser d&#8217;autres amines biog\u00e8nes telles que la putrescine et la cadav\u00e9rine. (Elmore Bo, et al. 2002).\r\n\r\nL&#8217;enzyme HNMT est exprim\u00e9e dans divers tissus et organes de notre corps, en particulier dans les reins et le foie, \u00e9galement dans la rate, le c\u00f4lon, la prostate, les ovaires, les cellules de la moelle \u00e9pini\u00e8re, la trach\u00e9e et les voies respiratoires. (Maintz, L. 2007).\r\n<h2><strong>La principale voie d&#8217;entr\u00e9e dans l&#8217;organisme de l&#8217;histamine provenant des aliments est l&#8217;\u00e9pith\u00e9lium intestinal.<\/strong><\/h2>\r\nPar cons\u00e9quent, bien que la HNMT soit \u00e9galement pr\u00e9sente dans le tractus gastro-intestinal, c&#8217;est l&#8217;enzyme DAO qui joue un r\u00f4le majeur dans la protection de l&#8217;organisme contre l&#8217;histamine exog\u00e8ne, celle qui provient des aliments. (Bohem T. et al. 2019 ; Mar\u0161avelski A, et al 2018)\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1c03125b elementor-section-content-middle elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1c03125b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-387fb1d5\" data-id=\"387fb1d5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-20c9622e elementor-widget elementor-widget-image\" data-id=\"20c9622e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.xeviverdaguer.com\/es\/cuando-te-pica-un-mosquito-te-deja-una-gran-mancha-roja-en-la-piel-dao\/\" target=\"_blank\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"126\" src=\"https:\/\/naturdao.com\/wp-content\/uploads\/2019\/12\/inst_xevi.png\" class=\"attachment-large size-large wp-image-9224\" alt=\"\" srcset=\"https:\/\/naturdao.com\/wp-content\/uploads\/2019\/12\/inst_xevi.png 400w, https:\/\/naturdao.com\/wp-content\/uploads\/2019\/12\/inst_xevi-300x95.png 300w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-1b4e09cf\" data-id=\"1b4e09cf\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e362d1 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"e362d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/Anna-Nadal.jpg\" class=\"attachment-full size-full wp-image-16637\" alt=\"\" srcset=\"https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/Anna-Nadal.jpg 300w, https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/Anna-Nadal-100x100.jpg 100w, https:\/\/naturdao.com\/wp-content\/uploads\/2022\/07\/Anna-Nadal-150x150.jpg 150w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Anna Nadal<\/h3><p class=\"elementor-image-box-description\">Kin\u00e9sith\u00e9rapeute et Postgradu\u00e9 en PNIE<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>L&#8217;histamine, amine bioactive, est synth\u00e9tis\u00e9e par d\u00e9carboxylation de son acide amin\u00e9 pr\u00e9curseur, l&#8217;histidine, dans une r\u00e9action enzymatique d\u00e9crite pour la premi\u00e8re fois par Windaus et Vogt en 1907. Synth\u00e8se d&#8217;histamine par d\u00e9carboxylation de son acide amin\u00e9 pr\u00e9curseur Le nom histamine vient du grec histos signifiant tissu, car il est pr\u00e9sent dans de nombreux tissus de [&hellip;]<\/p>\n","protected":false},"author":872,"featured_media":196000,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[56],"tags":[],"class_list":["post-16765","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-des-articles"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.0.1 - aioseo.com -->\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Dani\"\/>\n\t<meta name=\"google-site-verification\" content=\"googlec0b8607c1a0a6fdc.html\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/naturdao.com\/fr\/quand-fut-decouverte-lhistamine-et-par-qui\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.0.1\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/naturdao.com\\\/fr\\\/quand-fut-decouverte-lhistamine-et-par-qui\\\/#article\",\"name\":\"Quand fut d\\u00e9couverte l\\u2019histamine et par qui? 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