{"id":200588,"date":"2025-02-24T12:00:43","date_gmt":"2025-02-24T11:00:43","guid":{"rendered":"https:\/\/naturdao.com\/mastocytes-nutraceutiques-et-allergies-strategies-nutritionnelles-pour-la-regulation-immunologique\/"},"modified":"2025-03-07T12:00:32","modified_gmt":"2025-03-07T11:00:32","slug":"mastocytes-nutraceutiques-et-allergies-strategies-nutritionnelles-pour-la-regulation-immunologique","status":"publish","type":"post","link":"https:\/\/naturdao.com\/fr\/mastocytes-nutraceutiques-et-allergies-strategies-nutritionnelles-pour-la-regulation-immunologique\/","title":{"rendered":"Mastocytes, nutraceutiques et allergies : strat\u00e9gies nutritionnelles pour la r\u00e9gulation immunologique"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"200588\" class=\"elementor elementor-200588 elementor-200474\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-59c65e2 e-flex e-con-boxed e-con e-parent\" data-id=\"59c65e2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8b73a87 elementor-widget elementor-widget-text-editor\" data-id=\"8b73a87\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Plus de 30 % de la population mondiale souffre de certains types d\u2019allergies, et ce chiffre continue d&#8217;augmenter. Les allergies les plus courantes incluent celles caus\u00e9es par le pollen, les acariens, les squames d\u2019animaux et certains aliments.<\/p>\n<p>La forte pr\u00e9valence de ces maladies est due \u00e0 une combinaison <strong>de facteurs g\u00e9n\u00e9tiques et environnementaux.<\/strong><\/p>\n<p>Bien que certaines personnes aient une pr\u00e9disposition g\u00e9n\u00e9tique \u00e0 d\u00e9velopper des allergies, l\u2019environnement joue \u00e9galement un r\u00f4le important. L\u2019exposition \u00e0 des contaminants, les changements dans l\u2019alimentation et le mode de vie moderne peuvent alt\u00e9rer la r\u00e9ponse du syst\u00e8me immunitaire, entra\u00eenant des r\u00e9actions exag\u00e9r\u00e9es face \u00e0 des substances qui ne devraient pas repr\u00e9senter une menace.<\/p>\n<h3><strong>Quelle relation les mastocytes ont-ils avec les allergies ?<\/strong><\/h3>\n<p><strong>Les allergies<\/strong> sont des r\u00e9actions exag\u00e9r\u00e9es du syst\u00e8me immunitaire face \u00e0 des substances inoffensives, appel\u00e9es allerg\u00e8nes. Parmi les allerg\u00e8nes les plus courants, on trouve le pollen, les acariens, les poils d\u2019animaux et certains aliments comme les arachides ou les fruits de mer.<\/p>\n<p>Imaginons que le syst\u00e8me immunitaire soit une \u00e9quipe de s\u00e9curit\u00e9 d\u2019un b\u00e2timent. Son travail est de prot\u00e9ger le corps contre les menaces r\u00e9elles, comme les virus et les bact\u00e9ries. Cependant, chez les personnes allergiques, cette \u00e9quipe se trompe et r\u00e9agit de mani\u00e8re exag\u00e9r\u00e9e face \u00e0 des substances inoffensives.<\/p>\n<p>Cette r\u00e9ponse disproportionn\u00e9e est ce que nous appelons une <strong>r\u00e9action allergique<\/strong>.<\/p>\n<p>Lorsqu&#8217;une personne allergique entre en contact avec un allerg\u00e8ne, son syst\u00e8me immunitaire <strong>active les mastocytes<\/strong>, d\u00e9clenchant des sympt\u00f4mes tels que :<\/p>\n<ul>\n<li>\u00c9ternuements et \u00e9coulement nasal<\/li>\n<li>D\u00e9mangeaisons de la peau ou \u00e9ruptions cutan\u00e9es<\/li>\n<li>Inflammation de la gorge ou difficult\u00e9 \u00e0 respirer<\/li>\n<li>Yeux rouges et larmoyants<\/li>\n<\/ul>\n<p>Le terme <em>allergie<\/em> a \u00e9t\u00e9 introduit au XXe si\u00e8cle par le scientifique Clemens von Pirquet, qui observa que <strong>le syst\u00e8me immunitaire peut prot\u00e9ger, mais aussi causer une hypersensibilit\u00e9.<\/strong><\/p>\n<p>Les <strong>mastocytes<\/strong> sont des cellules du syst\u00e8me immunitaire charg\u00e9es de d\u00e9tecter d\u2019\u00e9ventuelles menaces. Ils se trouvent en grande quantit\u00e9 dans :<\/p>\n<ul>\n<li>La peau (provoquent des d\u00e9mangeaisons ou des \u00e9ruptions cutan\u00e9es).<\/li>\n<li>Les poumons (causent des sympt\u00f4mes respiratoires).<\/li>\n<li>L\u2019intestin (g\u00e9n\u00e8rent des r\u00e9actions \u00e0 certains aliments).<\/li>\n<\/ul>\n<p>Ces cellules contiennent des substances chimiques, dont l&#8217;<strong>histamine<\/strong>, responsable des sympt\u00f4mes allergiques.<\/p>\n<h2><strong>Comment les mastocytes sont-ils activ\u00e9s ?<\/strong><\/h2>\n<h3><strong><u>Activation d\u00e9pendante des IgE (Immunoglobuline E)<\/u><\/strong><\/h3>\n<p>C\u2019est le m\u00e9canisme le plus courant dans les allergies :<\/p>\n<ol>\n<li><strong>Sensibilisation :<\/strong> la premi\u00e8re fois qu\u2019une personne allergique entre en contact avec un allerg\u00e8ne, son syst\u00e8me immunitaire produit des anticorps IgE sp\u00e9cifiques.<\/li>\n<li><strong>Association aux mastocytes :<\/strong> l\u2019IgE se lie aux r\u00e9cepteurs <strong>Fc\u03b5RI<\/strong> sur la membrane des mastocytes, les pr\u00e9parant \u00e0 de futures r\u00e9actions.<\/li>\n<li><strong>Lib\u00e9ration d\u2019histamine :<\/strong> l\u2019allerg\u00e8ne active les mastocytes, qui lib\u00e8rent de l\u2019histamine et d&#8217;autres m\u00e9diateurs inflammatoires.<\/li>\n<\/ol>\n<p>Cette activation entra\u00eene des sympt\u00f4mes tels que <strong>des d\u00e9mangeaisons, une inflammation, des rougeurs, une congestion nasale et des difficult\u00e9s respiratoires.<\/strong><\/p>\n<h3><strong><u>Activation ind\u00e9pendante des IgE<\/u><\/strong><\/h3>\n<p>Les mastocytes peuvent \u00e9galement \u00eatre activ\u00e9s sans IgE, en r\u00e9ponse \u00e0 :<\/p>\n<ul>\n<li><strong>Substances chimiques et m\u00e9dicaments :<\/strong> certains m\u00e9dicaments peuvent activer les mastocytes sans IgE, provoquant des pseudo-allergies.<\/li>\n<li><strong>R\u00e9cepteurs de reconnaissance de motifs (TLR) :<\/strong> ils d\u00e9tectent les pathog\u00e8nes et activent les mastocytes pour d\u00e9fendre l\u2019organisme.<\/li>\n<li><strong>Cytokines pro-inflammatoires :<\/strong> des mol\u00e9cules comme <strong>IL-33, TSLP et IFN-\u03b3<\/strong> peuvent stimuler la lib\u00e9ration d\u2019histamine et d&#8217;autres substances pro-inflammatoires.<\/li>\n<\/ul>\n<h3><strong>Que se passe-t-il lorsque les mastocytes sont activ\u00e9s ?<\/strong><\/h3>\n<p>Ils lib\u00e8rent une grande quantit\u00e9 de substances inflammatoires, provoquant des sympt\u00f4mes allergiques et inflammatoires.<\/p>\n<p>Les m\u00e9diateurs les plus importants sont :<\/p>\n<ul>\n<li><strong>Histamine :<\/strong> responsable de l\u2019inflammation, des rougeurs, des d\u00e9mangeaisons et de l\u2019augmentation de la perm\u00e9abilit\u00e9 vasculaire.<\/li>\n<li><strong>Prot\u00e9ases (tryptase, chymase) :<\/strong> des enzymes contribuant \u00e0 l\u2019inflammation et \u00e0 la remodelage des tissus.<\/li>\n<li><strong>Eicosano\u00efdes (prostaglandines et leucotri\u00e8nes) :<\/strong> des substances d\u00e9riv\u00e9es des acides gras qui amplifient l\u2019inflammation.<\/li>\n<li><strong>Cytokines et chimiokines :<\/strong> des messagers chimiques qui r\u00e9gulent la r\u00e9ponse immunitaire et attirent d\u2019autres cellules inflammatoires.<\/li>\n<\/ul>\n<h2><strong>Les nutraceutiques et leur impact sur les mastocytes<\/strong><\/h2>\n<p>Le terme <em>nutraceutique<\/em> a \u00e9t\u00e9 cr\u00e9\u00e9 en 1989 par Stephen DeFelice, combinant nutrition et pharmacie. Il est d\u00e9fini comme :<\/p>\n<blockquote><p>\u201cUn aliment ou une partie d\u2019un aliment qui procure des b\u00e9n\u00e9fices m\u00e9dicaux ou de sant\u00e9, y compris la pr\u00e9vention et le traitement des maladies\u201d<\/p><\/blockquote>\n<h3><strong>Comment peuvent-ils influencer les mastocytes ?<\/strong><\/h3>\n<p>Les nutraceutiques ne se contentent pas de nourrir, ils peuvent \u00e9galement aider \u00e0 contr\u00f4ler des maladies, y compris la r\u00e9gulation de l\u2019activation des mastocytes dans les r\u00e9actions allergiques. Ce sont des aliments qui contiennent des compos\u00e9s bioactifs capables de moduler l\u2019activation des mastocytes et de r\u00e9duire l\u2019inflammation.<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter size-full wp-image-200544\" src=\"https:\/\/naturdao.com\/wp-content\/uploads\/2025\/02\/mastocitos_histaminac.png\" alt=\"Mastocytes et histamine\" width=\"864\" height=\"602\" srcset=\"https:\/\/naturdao.com\/wp-content\/uploads\/2025\/02\/mastocitos_histaminac.png 864w, https:\/\/naturdao.com\/wp-content\/uploads\/2025\/02\/mastocitos_histaminac-300x209.png 300w, https:\/\/naturdao.com\/wp-content\/uploads\/2025\/02\/mastocitos_histaminac-768x535.png 768w, https:\/\/naturdao.com\/wp-content\/uploads\/2025\/02\/mastocitos_histaminac-800x557.png 800w\" sizes=\"(max-width: 864px) 100vw, 864px\" \/><\/p>\n<p><strong>Figure :<\/strong> divers compos\u00e9s alimentaires qui peuvent influencer l\u2019activation des mastocytes, r\u00e9duisant l\u2019inflammation. Sina Kaag (2023)<\/p>\n<h3><strong>Lipides<\/strong><\/h3>\n<h3><strong>Acides gras polyinsatur\u00e9s (AGPI)<\/strong><\/h3>\n<p>Ces acides gras ont des propri\u00e9t\u00e9s anti-inflammatoires et peuvent moduler l\u2019activation des mastocytes, r\u00e9duisant la production d\u2019histamine et de cytokines.<\/p>\n<p><strong>Aliments riches en AGPI :<\/strong><\/p>\n<ul>\n<li><strong>Acide alpha-linol\u00e9nique (ALA) :<\/strong> graines de chia, lin, noix, soja, huile de canola.<\/li>\n<li><strong>Acide eicosapenta\u00e9no\u00efque (EPA) et docosahexa\u00e9no\u00efque (DHA) :<\/strong> poissons gras (saumon, sardines, thon, maquereau, hareng).<\/li>\n<li><strong>Acide arachidonique (AA) :<\/strong> viande rouge bio, \u0153ufs, fruits de mer.<\/li>\n<\/ul>\n<h3><strong>Acides gras \u00e0 cha\u00eene courte (AGCC)<\/strong><\/h3>\n<p>Les AGCC ont un effet b\u00e9n\u00e9fique sur le microbiote intestinal, aidant \u00e0 r\u00e9guler le syst\u00e8me immunitaire et \u00e0 r\u00e9duire l\u2019inflammation.<\/p>\n<p><strong>Aliments favorisant la production d\u2019AGCC :<\/strong><\/p>\n<ul>\n<li><strong>Butyrate :<\/strong> beurre, ghee, fromage affin\u00e9, produits ferment\u00e9s (k\u00e9fir, yaourt, choucroute, miso, kombucha).<\/li>\n<li><strong>Ac\u00e9tate :<\/strong> vinaigre de cidre de pomme.<\/li>\n<li><strong>Propionate :<\/strong> fromage Emmental.<\/li>\n<li>Aliments riches en amidon r\u00e9sistant (contribuent \u00e0 la production d\u2019AGCC) : l\u00e9gumineuses, bananes vertes, pommes de terre, riz et c\u00e9r\u00e9ales cuits puis refroidis entre 12 et 24 heures.<\/li>\n<\/ul>\n<h3><strong>Vitamines<\/strong><\/h3>\n<p>Les vitamines liposolubles, comme la vitamine D, jouent un r\u00f4le important dans la r\u00e9gulation du syst\u00e8me immunitaire, aidant \u00e0 contr\u00f4ler l\u2019activation des mastocytes.<\/p>\n<p><strong>Aliments riches en vitamine D :<\/strong><\/p>\n<ul>\n<li><strong>Poissons gras :<\/strong> saumon, thon, sardines.<\/li>\n<li>\u0152ufs.<\/li>\n<li>Champignons expos\u00e9s au soleil.<\/li>\n<li>Exposition solaire responsable (fondamentale pour synth\u00e9tiser la vitamine D \u00e0 travers la peau).<\/li>\n<\/ul>\n<h3><strong>Acides amin\u00e9s<\/strong><\/h3>\n<p>Certaines acides amin\u00e9s non essentiels peuvent moduler l\u2019inflammation et l\u2019activit\u00e9 des mastocytes.<\/p>\n<p><strong>Aliments riches en acides amin\u00e9s immunomodulateurs :<\/strong><\/p>\n<ul>\n<li><strong>Arginine :<\/strong> viandes maigres, poisson, produits laitiers, fruits \u00e0 coque (noix, amandes, noisettes), l\u00e9gumineuses (pois chiches, lentilles).<\/li>\n<li><strong>Glutamine :<\/strong> viandes, poissons, \u0153ufs, produits laitiers, \u00e9pinards, persil, betterave, chou, haricots.<\/li>\n<li><strong>Glycine :<\/strong> bouillon d\u2019os bio, g\u00e9latine, poulet, poisson, \u00e9pinards, chou fris\u00e9, graines de courge.<\/li>\n<\/ul>\n<h3><strong>Carot\u00e9no\u00efdes (pigments v\u00e9g\u00e9taux aux propri\u00e9t\u00e9s antioxydantes)<\/strong><\/h3>\n<p>Les carot\u00e9no\u00efdes aident \u00e0 r\u00e9guler la r\u00e9ponse immunitaire et ont des effets anti-inflammatoires sur les mastocytes.<\/p>\n<p><strong>Aliments riches en carot\u00e9no\u00efdes :<\/strong><\/p>\n<ul>\n<li><strong>Fucoxanthine :<\/strong> algues marines (wakame, nori).<\/li>\n<li><strong>Astaxanthine :<\/strong> saumon, truite, crevettes, homards, crabes.<\/li>\n<li><strong>Licop\u00e8ne :<\/strong> tomates, past\u00e8que, pamplemousse rose, poivron rouge, goyave.<\/li>\n<\/ul>\n<h3><strong>\u00c9pices aux propri\u00e9t\u00e9s anti-inflammatoires<\/strong><\/h3>\n<p>Certaines \u00e9pices peuvent bloquer l\u2019activation des mastocytes et r\u00e9duire la lib\u00e9ration d\u2019histamine et de cytokines.<\/p>\n<p><strong>Aliments riches en ces compos\u00e9s :<\/strong><\/p>\n<ul>\n<li><strong>Curcuma :<\/strong> curcumine, bisd\u00e9m\u00e9thoxycurcumine.<\/li>\n<li><strong>Cannelle :<\/strong> cinnamald\u00e9hyde.<\/li>\n<\/ul>\n<h3><strong>Compos\u00e9s ph\u00e9noliques (mol\u00e9cules bioactives des plantes aux effets immunomodulateurs)<\/strong><\/h3>\n<h3><strong>Flavono\u00efdes :<\/strong><\/h3>\n<p>Ce sont de puissants antioxydants et anti-inflammatoires, r\u00e9duisant la lib\u00e9ration d\u2019histamine et l\u2019activation des mastocytes.<\/p>\n<p><strong>Aliments riches en flavono\u00efdes :<\/strong><\/p>\n<ul>\n<li><strong>Kaempf\u00e9rol :<\/strong> brocoli, \u00e9pinards, chou fris\u00e9, pommes, raisins.<\/li>\n<li><strong>Querc\u00e9tine :<\/strong> oignons, pommes, raisins, th\u00e9 vert, baies, c\u00e2pres.<\/li>\n<li><strong>Lut\u00e9oline :<\/strong> persil, c\u00e9leri, poivrons verts, camomille.<\/li>\n<li><strong>Myric\u00e9tine :<\/strong> th\u00e9 noir, \u00e9pinards, bleuets, raisins, m\u00fbres.<\/li>\n<li><strong>Epigallocat\u00e9chine gallate (EGCG) :<\/strong> th\u00e9 vert.<\/li>\n<li><strong>Hesp\u00e9r\u00e9tine :<\/strong> agrumes (orange, citron, pamplemousse, mandarine).<\/li>\n<li><strong>Naring\u00e9nine :<\/strong> pamplemousse, orange, tomate, persil.<\/li>\n<\/ul>\n<h3><strong>Polym\u00e9thoxiflavono\u00efdes<\/strong><\/h3>\n<p>Ces flavono\u00efdes sp\u00e9cialis\u00e9s ont un fort effet anti-inflammatoire.<\/p>\n<p><strong>Aliments riches en polym\u00e9thoxiflavono\u00efdes :<\/strong><\/p>\n<ul>\n<li><strong>Nobiletine :<\/strong> \u00e9corces d\u2019agrumes (oranges, mandarines, citrons).<\/li>\n<li><strong>Tanger\u00e9tine :<\/strong> mandarines, oranges.<\/li>\n<\/ul>\n<h3><strong>Stilb\u00e8nes<\/strong><\/h3>\n<p>Ce sont de puissants antioxydants ayant la capacit\u00e9 de moduler l\u2019inflammation.<\/p>\n<p><strong>Aliments riches en stilb\u00e8nes :<\/strong><\/p>\n<ul>\n<li><strong>Resv\u00e9ratrol :<\/strong> raisins, cacahu\u00e8tes, m\u00fbres, pistaches.<\/li>\n<\/ul>\n<p>Incorporer ces aliments dans l\u2019alimentation peut aider \u00e0 r\u00e9duire l\u2019inflammation et am\u00e9liorer le contr\u00f4le des r\u00e9actions allergiques en modulant l\u2019activation des mastocytes. <em>\u00c0 l\u2019exception des personnes allergiques \u00e0 l\u2019un des aliments mentionn\u00e9s.<\/em><\/p>\n<blockquote><p>Pour obtenir les m\u00eames bienfaits sans risque, il est possible de rechercher des aliments alternatifs contenant des compos\u00e9s similaires mais sans potentiel allerg\u00e8ne.<\/p><\/blockquote>\n<p>Bien que la nutrition puisse jouer un r\u00f4le important dans la modulation de la r\u00e9ponse immunitaire, il est essentiel d\u2019adapter l\u2019alimentation \u00e0 chaque individu, notamment en ce qui concerne les allergies alimentaires.<\/p>\n<p><em>L\u2019objectif est de profiter des effets b\u00e9n\u00e9fiques des compos\u00e9s bioactifs, sans compromettre la s\u00e9curit\u00e9 du patient.<\/em><\/p>\n<p>La r\u00e9gulation des mastocytes par l\u2019alimentation est une strat\u00e9gie accessible et naturelle, pouvant \u00eatre utilis\u00e9e en compl\u00e9ment des traitements conventionnels et de la suppl\u00e9mentation.<\/p>\n<p>Bien que des \u00e9tudes aient montr\u00e9 que certains compos\u00e9s sous forme de suppl\u00e9ments ont des effets b\u00e9n\u00e9fiques, il est important de souligner que ces m\u00eames compos\u00e9s se trouvent dans certains aliments.<\/p>\n<p><strong>Ainsi, une alimentation riche en flavono\u00efdes, polyph\u00e9nols, carot\u00e9no\u00efdes, acides gras essentiels et \u00e9pices anti-inflammatoires peut contribuer \u00e0 moduler la r\u00e9ponse des mastocytes et \u00e0 r\u00e9duire l\u2019inflammation.<\/strong><\/p>\n<p>L\u2019utilisation de composants alimentaires ayant des effets immunomodulateurs repr\u00e9sente une alternative prometteuse pour la pr\u00e9vention et la gestion des maladies allergiques li\u00e9es aux mastocytes.<\/p>\n<blockquote><p><em>Si une aide est n\u00e9cessaire pour personnaliser l\u2019alimentation, il est recommand\u00e9 de consulter un di\u00e9t\u00e9ticien ou nutritionniste sp\u00e9cialis\u00e9 en psycho-neuro-immunologie.<\/em><\/p><\/blockquote>\n<p>Cette approche est une opportunit\u00e9 tant pour les futures recherches que pour les strat\u00e9gies de nutrition personnalis\u00e9e dans la gestion des maladies allergiques et des troubles li\u00e9s \u00e0 l&#8217;activation des mastocytes.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-474ab05 e-flex e-con-boxed e-con e-parent\" data-id=\"474ab05\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3470c45 elementor-widget elementor-widget-text-editor\" data-id=\"3470c45\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>R\u00c9F\u00c9RENCES<\/strong><del><\/p>\n<hr \/>\n<p><\/del><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ecaf377 elementor-widget elementor-widget-text-editor\" data-id=\"ecaf377\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol>\n<li style=\"list-style-type: none;\">\n<ol>\n<li>Sina Kaag and Alex Lorentz. Effects of Dietary Components on Mast Cells: Possible Use as Nutraceuticals for Allergies? Cells 2023, 12, 2602.<\/li>\n<li>Roger, A.; Basagana, M.; Teniente-Serra, A.; Depreux, N.; Jurgens, Y.; Padro, C.; Miquel, S.; Elduque, C.; Martinez-Caceres, E.M.<\/li>\n<li>Immunotheraphy in Allergic Diseases. Curr. Pharm. Des. 2018, 24, 1174\u20131194.<\/li>\n<li>Shamji, M.H.; Boyle, R.J. Allergic diseases and novel targets in allergen immunotherapy. Clin. Exp. Allergy 2021, 51, 1526\u20131528.<\/li>\n<li>Poncet, P.; S\u00e9n\u00e9chal, H.; Charpin, D. Update on pollen-food allergy syndrome. Expert Rev. Clin. Immunol. 2020, 16, 561\u2013578.<\/li>\n<li>Pawankar, R., et al. Allergic diseases and their impact on public health.World Allergy Organization Journal, 2020.<\/li>\n<li>Martino, D., et al. Influence of diet on the epigenome and implications for human health. Nature Communications, 2016.<\/li>\n<li>Liu, X., et al. Effects of polyphenols on mast cell-mediated allergic inflammation. Journal of Nutritional Biochemistry, 2017.<\/li>\n<li>Gupta, S., et al. Curcumin: A natural anti-inflammatory agent. Advances in Experimental Medicine and Biology, 2013.<\/li>\n<li>Park, H.-H.; Lee, S.; Son, H.-Y.; Park, S.-B.; Kim, M.-S.; Choi, E.-J.; Singh, T.S.K.; Ha, J.-H.; Lee, M.-G.; Kim, J.-E.; et al. Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. Arch. Pharm. Res. 2008, 31,1303\u20131311.<\/li>\n<li>Zeng,W.; Jin, L.; Zhang, F.; Zhang, C.; Liang,W. Naringenin as a potential immunomodulator in therapeutics. Res.2018, 135, 122\u2013126.<\/li>\n<li>Makuch, S.; Wi\u02dbecek, K.; Wo\u00b4zniak, M. The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell. Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis. Pharmaceuticals 2021, 14, 309.<\/li>\n<li>Vitte, J.; Vibhushan, S.; Bratti, M.; Montero-Hern\u00e1ndez, J.E.; Blank, U. Allergy, Anaphylaxis and Non-Allergic Hypersensitivity: IgE, Mast Cells and Beyond. Princ. Pract. 2022, 31, 501\u2013515.<\/li>\n<li>Dima, C.; Assadpour, E.; Dima, S.; Jafari, S.M. Bioavailability of nutraceuticals: Role of the food matrix, processing conditions, the gastrointestinal tract, and nanodelivery systems. Compr. Rev. Food Sci. Food Saf. 2020, 19, 954\u2013994.<\/li>\n<li>Zhao, J.-W.; Ping, J.-D.; Wang, Y.-F.; Liu, X.-N.; Li, N.; Hu, Z.-L.; Ming, L. Vitamin D suppress the production of vascular endothelial growth factor in mast cell by inhibiting PI3K\/Akt\/p38 MAPK\/HIF-1\u2000 pathway in chronic spontaneous urticaria.Clin. Immunol. 2020, 215, 108444.<\/li>\n<li>Park, B.-K.; Park, S.; Park, J.-B.; Park, M.C.; Min, T.S.; Jin, M. Omega-3 fatty acids suppress Th2-associated cytokine gene expressions and GATA transcription factors in mast cells. J. Nutr. Biochem. 2013, 24, 868\u2013876.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Plus de 30 % de la population mondiale souffre de certains types d\u2019allergies, et ce chiffre continue d&#8217;augmenter. Les allergies les plus courantes incluent celles caus\u00e9es par le pollen, les acariens, les squames d\u2019animaux et certains aliments. La forte pr\u00e9valence de ces maladies est due \u00e0 une combinaison de facteurs g\u00e9n\u00e9tiques et environnementaux. 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