Diamine oxidase supplementation improves symptoms in patients with histamine intolerance
- Wolfgang J. Schnedl, Michael Schenk, Sonja Lackner, Dietmar Enko, Harald Mangge & Florian Forster
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Food Sci Biotechnol (2019) 28(6):1779–1784
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https://doi.org/10.1007/s10068-019-00627-3
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ENGLISH
ABSTRACTO
Histamine intolerance (HIT) is thought to be caused by a disproportionate amount of histamine in the body. The enzyme diamine oxidase (DAO) is considered for the gastrointestinal degradation of histamine.
For this open-label interventional pilot study, we identified 28 patients with HIT. For 4 weeks, they were instructed to take DAO capsules before meals. Then, throughout a follow-up period, they were instructed not to take the DAO.
We used a questionnaire that included 22 symptoms, which were divided into 4 categories, as well as a symptom severity score. All symptoms improved significantly during the oral supplementation of DAO. During the follow-up period, without DAO supplementation, the symptoms sum scores increased again. The symptom intensity score was reduced for all symptoms.
We have demonstrated, a significant reduction of every HIT-related symptom and its intensity due to DAO oral supplements.